MENU A – Genetics
CMM 695D - Human Genetic Disease Colloquium
BIOC695, GENE695, MCB695, NRSC695, PSIO695; 3 credit hours; taught spring semester. Restifo
Course description: The course will cover a few medical genetic disorders in depth, with different topics each year. Clinical presentation, pathophysiology, genetic mechanisms and biochemical features will be considered. Readings will come mainly from the primary biomedical literature.
GENE 530 - Conservation Genetics
ECOL530, RNR530, WFSC530; 3 credit hours; taught fall semester. Culver
Course description: Basic methods and theories of genetic/genomic analyses together with the application of these analyses to promote conservation, proper management, and long term survival of free-ranging species, including the exploration of current conservation genetic/genomic literature. Graduate level requirements include a term project and an oral presentation
MCB 572A - Cell Systems
4 credit hours; taught fall semester. Weinert & Guttenkunst
Course description: Advanced treatment of regulation of basic cellular processes in both single-celled and multicellular eukaryotic organisms. Focus on experimental research aimed at understanding cellular networks and circuitry, as well as their evolution. An introduction to modeling cell systems will be embedded within the context of the course. This is primarily a discussion-based, student-led course.
PLP 528R - Microbial Genetics
GENE528, MCB528, MIC528, SWES528, ENVS528; 3 credit hours; taught spring semester. Cooper
Course description: Prokaryotic gene structure and function; methods of gene transfer and mapping, DNA structure, replication, transcription, and translation. Hands-on computer analysis of DNA sequences and gene cloning strategies. Principles of regulation of gene expression. Graduate-level requirements include a DNA sequence of an entire operon from any one of a variety of bacteria and additionally analyze one product from the operon using several GCG protein analysis programs plus an extensive exam.
MENU B – Biochemistry
BIOC 568 - Nucleic Acids, Metabolism, and Signaling
GENE 568, 4 credit hours, taught fall semester. Staff
Course description: Chemistry, structure, and function of nucleic acids; replication, transcription translation, gene organization, regulation of gene expression and organelle nucleic acids. Both prokaryotic and eukaryotic systems will be considered.
BIOC 565 - Proteins and Enzymes
3 credit hours, taught fall semester. Staff
Course description: Advanced consideration of enzyme structure and function.
BIOC 555 - Methods of Physical Biochemistry
3 credit hours, taught fall semester. Hausrath
Course description: The course will cover quantitative techniques commonly used in biochemistry research. It will include practical experience with data fitting and interpretation as well as description of the underlying theory.
BIOC 573 - Recombinant DNA Methods and Applications
MCB 573, MIC 573, PLS 573, GENE 573, 4 credit hours, taught spring semester. Staff
Course description: This course offers an intensive lab experience to teach students the practical and theoretical aspects of modern molecular biology. In the first part of the course, recombinant DNA methods and bioinformatics are used to clone and identify an unknown gene. In the second part of the course DNA microarray technology is used to determine the effect of environmental stress on the global gene expression program in yeast, and to identify genes that control the stress response. Weekly lectures compliment the lab sessions, covering the theory and principles underlying the experiments performed during the course.
CHEM 523A - Bioanalytical chemistry
3 credit hours, taught fall semester in odd numbered years. Staff
Course description: Bioanalytical chemistry covers the principles behind the essential measurements used for analysis of biological systems, including but not limited to separations, mass spectrometry, microarrays, immunoassays, and DNA sequencing. The current literature is examined to understand today's research questions in bioanalysis, developments in the biotech industry, and opportunities to have a creative impact on improving human health.
MENU C – Genomics
ABE 587 - Metagenomics: From Genes to Ecosystems
3 credits; taught fall semester. Hurwitz and Youensclark
Course description: This course focuses on the science of metagenomics towards understanding (1) questions that metagenomics can address, (2) possible approaches for metagenomic sequencing and analysis, and (3) how genes, pathways, and environmental context are translated into ecosystem-level knowledge. This course alternates between traditional lectures and hands-on experience with programming, bioinformatics tools, and metagenomic analysis. The course concludes with several weeks of seminar-format discussions on current research in metagenomic data analysis and a final project of your choice analyzing real-world experimental data.
MCB 553 - Functional and Evolutionary Genomics
BIOC 553; 4 credits; taught fall semester. Sanderson
Course description: Computational, functional, and evolutionary approaches to genomics, including bioinformatics and laboratory methods relevant to many modern research approaches in biology. Graduate-level requirements include students completing independently designed lab exercises and relate these to the primary literature in a paper.
GENE 677 - Principles of Genetic Association Studies
EPID 677; 3 credits; taught spring semester. Klimentidis
Course description: Topics: selection of appropriate study design for association studies; understanding basic molecular genetics with particular focus on the genetic code; selection of candidate genes; genotype analysis; temporal sequence in genetic association studies; importance of longitudinal data in genetic association studies; genotype versus haplotype analysis; selection of haplotype tagging SNPs; use of genetic software.
MCB 546 - Genetic and Molecular Networks
4 credits; taught spring semester. Staff
Course description: This course will explore the analysis of biological systems using genetic and molecular tools. Discussion of primary literature papers focusing on model systems.
GENE 526 - Population Genetics
ECOL 526; 3 units; offered spring semester. TBN
Course description: General introductory course on empirical and theoretical population genetics. It will involve two weekly lectures, weekly problem sets, and regular readings from the primary literature. A major goal of this course is to make students familiar with basic models of population genetics and to acquaint students with empirical tests of these models.